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Notify people that: Tramadol Hydrochloride Prolonged-Release is for oral use only and should be swallowed whole. The capsule really should not be chewed, dissolved, crushed or break up. Tramadol Hydrochloride Extended-Release may possibly trigger seizures and/or serotonin syndrome with concomitant utilization of serotonergic agents (like SRIs, NRIs